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0 · Proteogenomics Uncovers a Vast Repertoire of Shared Tumor
1 · Noncoding regions are the main source of targetable tumor
2 · Immunogenic stress and death of cancer cells: Contribution of
3 · Exploiting non
4 · Céline M. Laumont's research works
5 · Céline Laumont, a PhD student in Dr. Claude Perreault's
6 · Céline Laumont, IRIC Ph.D. graduate, is awarded a Banting
7 · Céline Laumont
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Dr. Céline Laumont, PhD Staff Scientist High-grade serous ovarian cancer is an aggressive .Céline M. Laumont is a Banting post-doctoral fellow working with Dr. Brad H. Nelson at the .
Céline M. Laumont's 24 research works with 1,098 citations and 2,587 reads, including: . Following the 2019-2020 Banting Postdoctoral Fellowships Competition, Céline . Abstract. Tumor-specific antigens (TSAs) represent ideal targets for cancer .
Céline M. Laumont. Institute for Research in Immunology and Cancer, . The goal of this study was to establish the global landscape of HGSC tumor .
Céline Laumont, a PhD student in Dr. Claude Perreault's laboratory, gave an .
Authors. Céline M Laumont 1 2 , Claude Perreault 3 4 5. Affiliations. 1 Institute for Research in . Céline M. Laumont 1,2 and Claude Perreault 1,2,3. Author information Article .
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor
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Jean-David Larouche 1 2 , Céline M Laumont 3 4 , Assya Trofimov 1 5 6 7 , Krystel Vincent 1 , Leslie Hesnard 1 , Sylvie Brochu 1 , Caroline Côté 1 . Montreal, Canada. 10 Department of Chemistry, Université de Montréal, Montréal, Canada. PMID: 38635416 DOI: 10.7554/eLife.91037 .Montreal, Quebec H3C 3J7, Canada. 2Department of Medicine, Université de Montréal, Montreal, Quebec H3C 3J7, Canada. 3 CHU Sainte-Justine, Université de Montréal, Montreal, Quebec H3T 1C5, Canada. 4 Department of Computer
Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Using an original proteogenomic approach, we analyzed the major histocompatibility complex class I (MHC class I)-associated immunopeptidome of 19 primary AML samples and identified 58 tumor-specific antigens (TSAs).Affiliations 1 Sorbonne Paris Cité, Université Paris Descartes, Paris, France.; 2 Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; 3 Institut National de la Santé et de la Recherche Médicale, U1138, Paris, France.; 4 Université Pierre et Marie Curie, Paris, France.; 5 Metabolomics and Cell Biology Platforms, Gustave .Perreault Claude currently works at the Department of Medicine, Université de Montréal. Perreault does research in Systems Biology, Immunology and Cancer Research.
Laumont CM, Daouda T, Laverdure JP, Bonneil E, Caron-Lizotte O, Hardy MP, et al. Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames. Nat Commun. 2016;7:10238. . Montreal, Quebec, H3T 1J4, Canada. Grégory Ehx & Claude Perreault. Authors. Grégory Ehx. View author publications.Classic adaptive CD8 T cells recognize major histocompatibility complex (MHC) class I-associated peptides (MIPs), and the ensemble of MIPs presented on the surface of a cell (the ‘immunopeptidome’) establishes its immunologic identity1,2,3.CD8 T cells are eminently self-referential and highly discriminant: they are selected on self-MIPs, sustained by self-MIPs and .
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Semantic Scholar profile for Céline M. Laumont, with 37 highly influential citations and 27 scientific research papers. Skip to search form Skip to main content Skip to account menu. Semantic Scholar's Logo. Search 222,152,302 papers from all fields of science. Search. Sign In . Self/non-self discrimination is a fundamental requirement of life (Boehm, 2012).In jawed vertebrates, the thymus is the only site where T lymphocytes can be properly educated to distinguish self from non-self (Boehm and Swann, 2014; Suo et al., 2022).This is vividly illustrated by Oncostatin M-transgenic mice, where T-cell production occurs exclusively in the lymph . Céline M. Laumont. Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Search for more papers by this authorThe Institute for Research in Immunology and Cancer of Université de Montréal provides the research community with a cutting-edge environment and research infrastructure, including the largest academic medicinal chemistry platform in the country, consistent with its genomics platform and its Centre for Advances Proteomics Analyses. Dr. Guy Sauvageau, Principal .
Qingchuan Zhao, Jean-Philippe Laverdure, Joël Lanoix, Chantal Durette, Caroline Côté, Éric Bonneil, Céline M. Laumont, Patrick Gendron, Krystel Vincent, Mathieu Courcelles, Sébastien Lemieux, Douglas G. Millar, Pamela S. Ohashi, Pierre Thibault, Claude Perreault; Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens . For decades, the global impact of genomic polymorphisms on the repertoire of peptides presented by major histocompatibility complex (MHC) has remained a matter of speculation. Here we present a novel approach that enables high-throughput discovery of polymorphic MHC class I-associated peptides (MIPs .
Laumont CM, Daouda T, Laverdure JP, Bonneil E, Caron-Lizotte O, Hardy MP, et al.. Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames. Nat Commun. (2016) 7:10238. 10.1038/ncomms10238 [PMC free article] [Google Scholar]IRIC is pleased to hold an international scientific symposium on October 19 th and 20 th 2023 to officially mark its 20 th anniversary!. Through its triple mission of acquiring new knowledge, training the next generation and accelerating the transformation of discoveries into therapeutic innovations, IRIC has proudly contributed over the past 20 years and continues to actively . Using mass spectrometry (MS) analysis of MHC class I immunopeptidome, Laumont et al. (47) estimated that cryptic antigens represent-ed~10% of MHC class I epitopes in leukemia patients. .
Céline M Laumont 1 2 , Tariq Daouda 1 2 3 , . Université de Montréal, PO Box 6128 Station Centre-Ville, Montreal, Quebec, Canada H3C 3J7. 5 Division of Hematology, Hôpital Maisonneuve-Rosemont, 5415 de l'Assomption Boulevard, Montreal, Quebec, Canada H1T 2M4. PMID: 26728094 As TE MAPs have been detected in normal and neoplastic extrathymic cells (Larouche et al., 2020; Laumont et al., 2018; Burbage et al., 2023; Shah et al., 2023), the presentation of TEs by mTECs is likely essential to central tolerance.Sylvie BROCHU | Cited by 1,196 | of Université de Montréal, Montréal (UdeM) | Read 55 publications | Contact Sylvie BROCHUPierre Thibault is a Professor in the Department of Chemistry and Biochemistry, Université de Montréal, and a principal investigator at the Institute for Research in Immunology and Cancer where .
Laumont CM, Daouda T, Laverdure JP, Bonneil E, Caron-Lizotte O, Hardy MP, et al. Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.
Sébastien LEMIEUX, Principal Investigator | Cited by 6,623 | of Université de Montréal, Montréal (UdeM) | Read 220 publications | Contact Sébastien LEMIEUX
Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic. . PO Box 6128 Station Centre-Ville .
CELINE LAUMONT My Original Poem: North of Prince George Victoria, BC . GOLD AWARD. The Gold award celebrates pieces which demonstrate the beauty of Japanese Calligraphy and exhibit sophisticated quality. These six different approaches to Japanese Calligraphy chosen for the award showcase high quality exemplary of recognition. . Montreal, QC . Inventors: Céline LAUMONT, Pierre THIBAULT, Sébastien LEMIEUX, Claude PERREAULT NOVEL MINOR HISTOCOMPATIBILITY ANTIGENS AND USES THEREOF Publication number: 20200055918
High-grade serous ovarian cancer (HGSC), the principal cause of death from gynecologic malignancies in the world, has not significantly benefited from advances in cancer immunotherapy. Although HGSC infiltration by lymphocytes correlates with superior survival, the nature of antigens that can elicit . Inventors: Céline Laumont, Pierre Thibault, Sébastien Lemieux, . Assignee: UNIVERSITE DE MONTREAL Inventors: Bruno Simoneau, Yves Chantigny, Jonathan Yeh, Guy Sauvageau, Anne Marinier NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE. Publication number: 20230165812 .
Noncoding regions are the main source of targetable tumor
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celine laumont montreal|Céline Laumont, a PhD student in Dr. Claude Perreault's
